Use of male essence to alter female endocrine response

US5155045A · kind A · utility

Assignee

• Trustees of the University of Penna · US

Inventors

• Winnifred B. Cutler · Haverford, US
• George Preti · Horsham, US
• Celso R. Garcia · Yeadon, US

Key dates

• Filing date: Apr 30, 1986
• Grant date: Oct 13, 1992
• Expiry date: Apr 30, 2006

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T436/203332
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A novel method for treating a human female is disclosed comprising the step of exposing the nasal region of said female to at least a portion of the axillary secretions of a human male. This exposure is preferably continued in amounts and for a duration which are effective to significantly alter an endocrine related characteristic, such as the menstrual cycle length, of that female. In particular, the portions of male axillary secretions to be exposed to the female preferably comprise one or more compounds such as androstenol, dehydroepiandrosterone, and/or a compound or compounds exhibiting a burnt heavy axiallary-like odor which elutes at about 50 minutes as shown on the FID response curve of FIG. 3B. Studies show that pooled male donor secretions are effective to alter aberrant menstrual cycles, particularly those exhibiting luteal phase defects such that they become presumptively fertile menstrual cycles having durations of about 29.5.+-.3 days. Symptoms of perimenopause, such as hot flashes, night sweats and irregular menstrual cycles, are also treatable using the methods of this invention, which tend to promote female endocrine regularity and longevity.