3-piperazinosydnone imines, process for their preparation and their use

US5155109A · kind A · utility

Assignee

• Cassella Aktiengesellschaft · DE

Inventors

• Karl Schonafinger · Alzenau, DE
• Helmut Bohn · Schöneck, DE
• Melitta Just · Langen, DE

Key dates

• Filing date: Jul 16, 1991
• Grant date: Oct 13, 1992
• Expiry date: Jul 16, 2011

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D271/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to pharmacologically active substituted 3-aminosydnone imines of the general formula I ##STR1## in which R.sup.1 denotes (C.sub.1 -C.sub.4)-alkyl, di-(C.sub.1 -C.sub.4)-alkylamino or (C.sub.6 -C.sub.12)-aryl, which can optionally be substituted by (C.sub.1 -C.sub.4)-alkyl; PA0 R.sup.2 denotes hydrogen or COR.sup.3 and R.sup.3 denotes (C.sub.1 -C.sub.4)-alkyl, (C.sub.1 -C.sub.4)-alkoxy, (C.sub.1 -C.sub.4)-alkoxy-(C.sub.1 -C.sub.4)-alkyl, acetoxy-(C.sub.1 -C.sub.4)-alkyl, (C.sub.6 -C.sub.12)-aryl, which can be substituted by (C.sub.1 -C.sub.4)-alkyl or (C.sub.1 -C.sub.4)-alkoxy, pyridyl, pyridyl(C.sub.1 -C.sub.4)alkyl or (C.sub.3 -C.sub.8)-cycloalkyl and their pharmacologically acceptable acid addition salts.