Phenylsulphonamide substituted pyridinealkene- and aminooxyalkanecarboxylic acid derivatives

US5155121A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Ulrich Niewohner · Wermelskirchen, DE
• Ulrich Muller · Wuppertal, DE
• Elisabeth Perzborn · Wuppertal, DE
• Erwin Bischoff · Wuppertal, DE
• Hans-Georg Dellweg · Wuppertal, DE

Key dates

• Filing date: Aug 2, 1991
• Grant date: Oct 13, 1992
• Expiry date: Aug 2, 2011

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D213/71
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The compounds according to the invention can be prepared by reaction of the corresponding amines with sulphonic acid derivatives, or in the case of the aminooxy compounds by reaction of ketones with aminooxy compounds or alkylation of hydroxylamines, or in the case of the alkene compounds by reaction of ketones with phosphorusylides. The phenylsulphonamide substituted pyridinealkene- and -aminooxyalkenecarboxylic acid derivatives can be used for the treatment of thromboembolic disorders, ischaemias, arteriosclerosis, allergies and asthma.