Microbial process for the production of immunosuppressive antibiotics
US5156960A · kind A · utility
Assignee
Inventors
- Antonia Jekkel nee Bokany
- Gabor Ambrus
- Eva Toth-Sarudy
- Istvan Mihaly
- Agota Hulber nee Dobos
- Attila Andor
- Karoly Albrecht
- Kalman Konczol
- Valeria Szell
- Eva Tomori nee Joszt
- Imre Moravcsik
- Kalman Polya
- Janos Erdei
- Lajos Kiss
- Bela Makadi
- Karoly Nagy
- Bela Palotas
- Etelka Deli nee Konszky
- Karoly Buzasi
- Aniko Molnar nee Antal
- Gyorgy Santha
- Vilma Szaszhegyesi
Key dates
| Filing date | Dec 20, 1989 |
| Grant date | Oct 20, 1992 |
| Priority date | — |
| Expiry date | Dec 20, 2009 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/911
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention relates to a microbial process for the production of immunosuppressive cyclosporine antibiotic complex or of its components, cyclosporine A, cyclosporine B and cyclosporine C, by the aerobic fermentation of a filamentous fungus strain biosynthesizing the above antibiotic(s) in a nutrient medium containing utilizable carbon and nitrogen sources as well as mineral salts, and by isolating the products formed, which comprises culturing a strain of the novel Tolypocladium varium fungus species producing the cyclosporine antibiotic complex, preferably tolypocladium varium sp. nov. CY/93, deposited at the National Collection of Agricultural and Industrial Microorganisms, Budapest, Hungary under the number NCAIM(P)F 001005, on a nutrient medium containing carbon sources, organic and inorganic nitrogen sources as well as mineral salts, under aerobic conditions, at 25.degree. to 30.degree. C., and, if desired, isolating and purifying the cyclosporine antibiotic complex or its components produced.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.