Organoboron reagents for the preparation of unsubstituted propargylic alcohols
US5157167A · kind A · utility
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Key dates
| Filing date | Jan 31, 1992 |
| Grant date | Oct 20, 1992 |
| Priority date | — |
| Expiry date | Jan 31, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F7/0803
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The novel organoboron reagent of the present invention is useful in the preparation of unsubstituted propargylic alcohols. This compound reacts with aldehydes and ketones cleanly to afford propargylic alcohols in excellent yields Unsubstituted propargylic alcohols are important synthetic intermediates in the synthesis of a number of natural products. In addition, the novel organoboron reagent of the present invention also demonstrates diastereomeric selectivity when reacted with enatiomerically pure aldehydes.
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