Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors
US5158936A · kind A · utility
34Cited by
5References
11Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 15, 1991 |
| Grant date | Oct 27, 1992 |
| Priority date | — |
| Expiry date | May 15, 2011 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Thiol protease inhibitors are disclosed having the formula: ##STR1## or an optical isomer thereof, or a pharmaceutically acceptable salt thereof, wherein: PA0 n is 0 or 1; PA1 m is 0, 1 or 2; PA1 X is H or an N-protecting group; PA0 each Y is independently an optionally protected .alpha.-amino acid residue; PA0 R is an optionally protected .alpha.-amino acid side chain that is H or CH.sub.3 or that is bonded to the .alpha.-carbon atom to which it is attached by a methylene, methine or phenyl radial; and PA0 R' is optionally substituted aryl.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.