2-substituted ergolines

US5158957A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Thomas Brumby · Berlin, DE
• Gerhard Sauer · Berlin, DE
• Josef Heindl · Berlin, DE
• Jonathan Turner · Berlin, DE
• Gerhard Kuhne · Berlin, DE
• Helmut Wachtel · Berlin, DE

Key dates

• Filing date: Jun 26, 1991
• Grant date: Oct 27, 1992
• Expiry date: Jun 26, 2011

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

2-Substituted ergolines ##STR1## wherein C.sub.2 C.sub.3 and C.sub.9 C.sub.10 represent a single of double bond; PA0 X is oxygen or sulfur; PA0 R.sup.2 is C.sub.1-10 alkyl, optionally halogen-substituted C.sub.2-10 alkenyl, CH.sub.2 YR.sup.3, CR.sup.12 (OR.sup.4)R.sup.5, CH.sub.2 --CHR.sup.9 --COR.sup.10 or COR.sup.12, PA0 wherein PA1 Y is oxygen or sulfur, PA1 R.sup.3 is hydrogen, C.sub.1-4 alkyl, phenyl, C.sub.2-5 acyl or phenyl C.sub.1-4 alkyl, PA1 R.sup.4 is hydrogen or C.sub.2-5 acyl, PA1 R.sup.5 is C.sub.1-9 alkyl, PA1 R.sup.9 is COCH.sub.3 or COO-C.sub.1-4 alkyl, PA1 R.sup.10 is C.sub.1-4 alkyl or O-C.sub.1-4 alkyl, PA1 R.sup.12 is hydrogen or C.sub.1-9 alkyl; and PA0 R.sup.6 is C.sub.2-10 alkyl, C.sub.3-10 alkenyl or C.sub.4-10 cycloalkyl-C.sub.1-3 -alkyl, and acid addition salts, isomers and isomeric mixtures thereof are dopaminergic agonists and useful for treating Parkinson's Disease.