7-oxabicycloheptyl substituted heterocyclic amide prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease
US5158967A · kind A · utility
14Cited by
10References
14Claims
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Key dates
| Filing date | Jun 12, 1991 |
| Grant date | Oct 27, 1992 |
| Priority date | — |
| Expiry date | Jun 12, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/65586
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
7-Oxabicycloheptyl substituted heterocyclic amide prostaglandin analogs are provided which are thromboxane A.sub.2 (TXA.sub.2) receptor antagonists or combined thromboxane A.sub.2 receptor antagonist/thromboxane synthetase inhibitors and have the structural formula ##STR1## wherein R is SO.sub.3 H, P(O)OR.sup.3 OH or P(O)R.sup.4 OH, X is O or NH, and Z, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined herein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.