Purification of crude Ioversol using reverse osmosis

US5160437A · kind A · utility

Assignee

• MallincKrodt Medical, Inc. · US

Inventors

• Mark E. Bosworth · Chesterfield, US
• Thomas J. Dunn · Cedar Hill, US
• Warren Hall · Del Mar, US
• Richard Johnson · Briarcliff Manor, US
• Mills T. Kneller · University City, US
• Youlin Lin · Chesterfield, US
• Rebecca A. Wallace · Manchester, US
• David H. White · Ballwin, US
• David M. Wong · Kirkwood, US

Key dates

• Filing date: Dec 3, 1991
• Grant date: Nov 3, 1992
• Expiry date: Dec 3, 2011

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C237/46
• WIPO field: Chemical engineering
• WIPO sector: Chemistry

Abstract

The use of reverse osmosis as an alternative or substitute method for the purification of a crude diagnostic agent. In the purification process a crude Ioversol solution is contacted with a cross-linked membrane under pressure, forcing the low molecular weight impurities within the crude Ioversol solution through the membrane pores and retaining Ioversol molecules.