Fragment of TNF-.alpha. for promoting wound healing
US5160483A · kind A · utility
14Cited by
12References
10Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 7, 1991 |
| Grant date | Nov 3, 1992 |
| Priority date | — |
| Expiry date | May 7, 2011 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method and composition for promoting the healing of an open wound, such as a fresh surgical incision, a decubitus ulcer, or a diabetes ulcer. The method includes applying to the wound a therapeutically effective amount of a composition comprising a protein fragment of tumor necrosis factor .alpha.(TNF-.alpha.) including amino acids 31 through 68 SEQ ID NO.: 1. The composition may be applied topically or injected locally into a wound or ulcer site. A preferred composition includes a carrier medium selected from sterile water, sterile saline, and albumin. Topical formulations are administered as sprays, gels, ointments or salves.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.