Patent · US Expired

11.beta.-substituted 16.alpha., 17.alpha.-methylene-estra-4,9-dien-3-ones

US5162312A · kind A · utility

5Cited by

1References

10Claims

0Family size

Assignee

SCHERING CORPORATION · US

Inventors

Helmut Kasch · Jena, DE
Reimar Krieg · Jena, DE
Anatoil Kurischko · Jena, DE
Kurt Ponsold · Jena, DE

Key dates

Filing date	Aug 15, 1990
Grant date	Nov 10, 1992
Priority date	—
Expiry date	Aug 15, 2010

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P35/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

11.beta.-substituted-16.alpha., 17.alpha.-methylene-estra-4,9-dien-3-ones of formula I ##STR1## wherein R.sup.1 is a methyl or ethyl group; PA0 R.sup.2 is H; a C.sub.1-6 -alkyl, -alkoxymethyl, -alkanoyl or -alkoxcarbonyl group ; 2-methoxyethyl; 2-hydroxyethyl; 2-C.sub.1-4 -alkanoyloxyethyl; or a tri-C.sub.1-4 -alkylsilyl group; PA0 R.sup.3 is vinyl; a C.sub.1-6 -alkyl; or a phenyl radical para-substituted by --OCH.sub.3, --SCH.sub.3, --N(CH.sub.3), --CN, --CHO, CH.sub.3 CO--, CH.sub.3 CHOH-- or --CH.sub.2 OH; PA0 R.sup.6 is H or a C.sub.1-4 -alkyl group; PA0 X is O, a hydroxy- or methoxyimino group (.dbd.N.about.OH or --N.about.OCH.sub.3), or a cyclic thioketal with 2 or 3 carbon ring atoms are provided, as well as pharmaceutical compositions containing said compounds, methods of use of said compounds, and processes for their production.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.