Circulation active 4-aminoaryldihydropryidine lactones

US5162338A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Siegfried Goldmann · Wuppertal, DE
• Matthias Schramm · Cologne, DE
• Rainer Gross · Wuppertal, DE
• Gunther Thomas · Wuppertal, DE
• Martin Bechem · Wuppertal, DE
• Michael Kayser · Hagen, DE

Key dates

• Filing date: Oct 18, 1991
• Grant date: Nov 10, 1992
• Expiry date: Oct 18, 2011

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

4 Aminoaryldihydropyridines of the formula ##STR1## in which R.sup.1 is hydrogen or an organic radical, preferably methyl or ethyl, PA1 R.sup.2 is hydrogen, C.sub.1 -C.sub.5 - alkyl, --CN, --NH.sub.2, --CH.sub.2 or --CH.sub.2 OH, preferably methyl, PA1 R.sup.3 is hydrogen or alkyl, preferably hydrogen, PA1 Y is --CO-- or --SO.sub.2 --, and PA1 R.sup.4 is an organic radical, or PA1 Y-R.sup.4 is hydrogen, and physiologically acceptable salts thereof, are circulation-active and effective for improving myocardial contractility, for raising blood pressure, for lowering blood sugar, for reducing mucosal swelling and for controlling the salt and fluid balance.