2-heteroatom containing urea and thiourea ACAT inhibitors
US5162360A · kind A · utility
124Cited by
3References
5Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 24, 1991 |
| Grant date | Nov 10, 1992 |
| Priority date | — |
| Expiry date | Jun 24, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D277/48
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides N-substituted aryl-N'-heterocyclic substituted ureas and thioureas of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are hydrogen, fluorine, chlorine, bromine, alkyl, alkoxy, substituted or unsubstituted benzoyl, substituted or unsubstituted phenyl, amino, substituted amino, or a monocyclic heterocyclic, or a carboxy group; and Het is a substituted monocyclic heterocyclic group containing two hetero atoms selected from nitrogen, oxygen or sulfur; which are useful in treating hypercholesterolemia and atherosclerosis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.