Method for reversibly arresting muscle activity

US5162374A · kind A · utility

Assignee

• University of Vermont and State Agricultural College · US

Inventors

• Louis A. Mulieri · South Burlington, US
• Gerd HASENFUSS · Bergneustadt, DE
• Norman R. Alpert · Shelburne, US

Key dates

• Filing date: Jun 12, 1991
• Grant date: Nov 10, 1992
• Expiry date: Jun 12, 2011

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/28
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Muscle activity can be reversibly arrested by administering a reagent, such as 2,3-butanedione monoxime (BDM), which selectively blocks the interaction of the contractile proteins actin and myosin. Muscle such as the heart is contacted with the reagent to arrest activity and, after surgery or transplantation, the reagent is removed from the muscle to restore muscle activity. The preferred reagent BDM has the following structure: ##STR1##