Process for preparing expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles
US5162509A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 18, 1990 |
| Grant date | Nov 10, 1992 |
| Priority date | — |
| Expiry date | Jun 18, 2010 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/546
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention involves a novel tripyrrole dimethine-derived "expanded porphyrin" (texaphyrin), the synthesis of such compounds, their analogs or derivatives and their uses. These expanded porphyrin-like macrocycles are efficient chelators of divalent and trivalent metal ions. Metal complexes of these compounds are active as photosensitizers for the generation of singlet oxygen and thus potentially for inactivation or destruction of human immunodeficiency virus (HIV-1), mononuclear or other cells infected with such virus and tumor cells as well. A variety of texaphyrin derivatives have been produced and many more are readily obtainable. Various metal (e.g., transition, main group, and lanthanide) complexes with the texaphyrin and texaphyrin derivatives of the present invention have unusual water solubility and stability which render them particularly useful. These metallotexaphyrin complexes have optical properties making them unique as compared to existing porphyrin-like or other macrocycles. For example, they absorb light strongly in a physilogically important region (i.e. 690-880 nm). These complexes also form long-lived triplet states in high yield and act as efficient p…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.