3-cyano-5,4'-bipyridine-1'-oxide compounds and pharmaceutical compositions and methods containing the same

US5162533A · kind A · utility

Assignee

• Arzneimittelwerk Dresden GmbH · DE

Inventors

• Erhard Klauschenz · Berlin, DE
• Volker Hagen · Berlin, DE
• Angela Hagen · Berlin, DE
• Peter Muschick · Ladenburg, DE
• Brigitte Schlegel · Berlin, DE
• Sabine Heer · Radebeul, DE
• Gottfried Faust · Berlin, DE
• Hans-Joachim Jansch · Radebeul, DE

Key dates

• Filing date: Mar 7, 1991
• Grant date: Nov 10, 1992
• Expiry date: Mar 7, 2011

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A 3-cyano-5,4'-bipyridine-1'-oxide of the formula ##STR1## and their pharmaceutically acceptable acid addition salts, wherein R is an amino, alkoxy, oxyalkoxy or chloro residue, have heart stimulating cardiotonic and vasodiolatory properties. They can be preparaed by (a) converting an R-substituted-3-cyano-bipyridine to its corresponding N-oxide, or (b) by substituting an R-residue or an R-unsubstituted precursor of the conpound of fomula (i), and if required, converting the product into its pharmaceutically acceptable acid addition salt.