Peptide analogues of insulin-like growth factor 1 (IGF-1) or factor 2 (IGF-2)

US5164370A · kind A · utility

Assignee

• Gropep PTY, Ltd. · AU

Inventors

• Francis John Ballard · Sydney, AU
• John C. Wallace · Adelaide, AU
• Julian R. E. Wells · Adelaide, AU

Key dates

• Filing date: Aug 24, 1989
• Grant date: Nov 17, 1992
• Expiry date: Aug 24, 2009

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S930/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Peptide analogues of insulin-like growth factor 1 and growth factor 2 are disclosed. When the analogue is an analogue of growth factor 1 the glutamic acid residue is absent from position 3 of the N-terminal and either the glutamic acid residue or the threonine residue adjacent to glutamic acid residue at position 3 is replaced by a different amino acid residue. When the peptide analogue is an analogue of insulin growth factor 2 the glutamic acid residue position 5 is absent. Preferred peptide analogues are disclosed. Methods of use in pharmaceutical and veterinary preparations are described.