Heterocyclic ketones

US5164371A · kind A · utility

Assignee

• ICI Americas, Inc. · US

Inventors

• Philip D. Edwards · Claymont, US
• Joseph J. Lewis · West Chester, US
• Charles W. Perkins · Wilmington, US
• Diane A. Trainor · Glen Mills, US
• Richard A. Wildonger · Elmwood, US

Key dates

• Filing date: May 11, 1988
• Grant date: Nov 17, 1992
• Expiry date: May 11, 2008

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K5/06191
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides a series of novel heterocyclic ketones of formula I ##STR1## and pharmaceutically acceptable base-addition salts thereof, in which the values of R.sup.4, L, A, X and Q have the meanings defined in the following specification. The compounds of formula I are inhibitors of human leukocytic elastase. The invention also provides pharmaceutical compositions containing a compound of formula I, or a pharmaceutically acceptable base-addition salt thereof, and processes and intermediates for the manufacture of compounds of formula I.