Pyrroloquinoline compounds
US5164400A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 13, 1990 |
| Grant date | Nov 17, 1992 |
| Priority date | — |
| Expiry date | Jul 13, 2010 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to a compound of the formula: ##STR1## in which R.sup.1 and R.sup.2 are each hydrogen or lower alkyl, PA0 R.sup.3 is aryl or unsaturated, 5- or 6-membered heterocyclic group containing a sulfur atom, each of which may be substituted by one or more substituent(s) selected from the group consisting of halogen, hydroxy, lower alkyl, aryloxy, trihalo(lower)alkyl, lower alkoxy and mono- or di(lower)alkylamino, PA0 R.sup.4 is hydrogen, halogen or lower alkyl, PA0 A is methylene, methine, oxa, thia, sulfinyl or sulfonyl, PA0 Y is vinylene or ethylene. PA0 Z is a group of the formula: ##STR2## wherein R.sup.5 is carboxy or protected carboxy, and PA1 R.sup.6 is hydrogen or hydroxy-protective group, and PA0 the line is of a single or double bond, or a pharmaceutically acceptable salt thereof, useful as a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.