Patent · US Expired

Manufacturing intravenous tolerable immunoglobulin-G preparation

US5164487A · kind A · utility

35Cited by

2References

15Claims

0Family size

Assignee

Biotest Pharma GmbH · DE

Inventors

Norbert Kothe · Kronberg, DE
Dieter Rudnick · Dreieich, DE
Detlef Piechaczek · Munster, DE
Herwald Klein · Weiterstadt, DE
Detlef Rohm · Darmstadt, DE
Michael Kloft · Weiterstadt, DE

Key dates

Filing date	Mar 15, 1991
Grant date	Nov 17, 1992
Priority date	—
Expiry date	Mar 15, 2011

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K39/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Method of manufacturing an intravenously tolerable immunoglobulin-G preparation that is free of aggregates, vasoactive substances and proteolytic enzymes and accordingly appropriate for all types of patients, especially immunosuppressed patients, from a starting material that contains immunoglobulin G but from which the coagulation factors have been removed. The starting material is treated with 0.4 to 1.5% by volume of octanoic acid and then chromatographed, especially on an ion or cation exchanger or hydrophobic matrix.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.