Lung growth stimulatory and inhibitory factors for carcinoma tumor cells
US5164489A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 23, 1988 |
| Grant date | Nov 17, 1992 |
| Priority date | — |
| Expiry date | May 23, 2008 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to the purification and characterization of growth stimulatory and inhibitory protein factors produced by various organs which appear to play a role in the successful formation of metastatic colonies of tumor cells. In particular, it has been found that syngeneic organs secrete protein growth stimulatory and inhibitory factors which can, at low concentrations, affect metastatic tumor cells. The ability of a malignant cell to respond to these factors is believed to be related to tumor cell metastasis to specific body organs. In particular a lung growth stimulatory glycoprotein having a molecular weight of approximately 66,000 daltons has been found to stimulate growth of lung-metastatic rat and human mammary tumor cells in serum deprived medium.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.