Protection of human corneal endothelial cells
US5166048A · kind A · utility
Inventors
Key dates
| Filing date | Aug 14, 1991 |
| Grant date | Nov 24, 1992 |
| Priority date | — |
| Expiry date | Aug 14, 2011 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA01N1/125
- WIPO fieldBasic materials chemistry
- WIPO sectorChemistry
Abstract
The cells of the coverings and linings of internal human and animal tissues, organs and body cavities subject to trauma, such as surgery, may be protected against exfoliation or destruction by the topical application or injection of effective amounts of chondroitin sulfate prior to or during the trauma. Preferably, the chondroitin sulfate is used in physiological solutions in concentrations of about 40 to 55 weight percent, and may be used as a surgical irrigating solution. Intraarticular injection of such chondroitin sulfate solutions into human and animal joints having degenerative joint conditions protects the joint cells, reduces aseptic inflammation and/or prevents further degeneration of cartilage tissue. Solutions for preserving human and animal cells and tissues in vitro for later in vivo use have extended storage life when chondroitin sulfate is added to such storage solutions in effective amounts such as about 1 to 20 weight percent of the storage solution.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.