Process for the production of 4-halo-3-hydroxybutyronitrile with Corynebacterium or Microbacterium
US5166061A · kind A · utility
13Cited by
1References
3Claims
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Key dates
| Filing date | Jul 20, 1990 |
| Grant date | Nov 24, 1992 |
| Priority date | — |
| Expiry date | Jul 20, 2010 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/843
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A process for the production of a 4-halo-3-hydroxybutyronitrile which comprises reacting a 1,3-dihalo-2-propanol with a dehalogenating enzyme originating from a Corynebacterium or a Microbacterium in the presence of an alkali cyanide to thereby convert the 1,3-dihalo-2-propanol into the 4-halo-3-hydroyxbutyronitrile and collecting the product thus formed is disclosed. According to this process, a 4-halo-3-hydroxybutyronitrile which is highly useful in the syntheses of various medicines and physiologically active substances can be easily and efficiently produced from an inexpensive starting material.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.