6-phenoxymethyl-4-hydroxytetrahydropyran-2-ones and 6-thiphenoxymethyl-4-hydroxytetrahydropyran-2-ones and the corresponding dihydroxycarboxylic acid derivatives, salts and esters, and in treating hypercholesterolemia

US5166171A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Heiner Jendralla · Frankfurt, DE
• Gunther Wess · Niederrodenbach, DE
• Wilhelm Bartmann
• Gerhard Beck · Frankfurt am Main, DE

Key dates

• Filing date: Apr 2, 1991
• Grant date: Nov 24, 1992
• Expiry date: Apr 2, 2011

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D309/30
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

6-Phenoxymethyl-4-hydroxytetrahydropyran-2-ones and 6-thiophenoxymethyl-4-hydroxytetrahydropyran-2-ones and the corresponding dihydroxycarboxylic acid derivatives, salts and esters, processes for the preparation of these compounds, their use as pharmaceuticals, pharmaceutical preparations and novel phenols and thiophenols Compounds of the general formula I ##STR1## and the corresponding open-chain dihydroxycarboxylic acids of the formula II ##STR2## in which X, Y and Z have the meanings given, and pharmacologically tolerated salts thereof with bases and pharmacologically tolerated esters thereof, processes for the preparation of these compounds, their use as pharmaceuticals and pharmaceutical preparations are described. Novel phenols and thiophenols of the formula III ##STR3## in which X, Y and Z have the meanings given, are also described.