Cecropin polypetides with activity against Gram-positive and Gram-negative bacteria
US5166321A · kind A · utility
20Cited by
3References
18Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 6, 1987 |
| Grant date | Nov 24, 1992 |
| Priority date | — |
| Expiry date | Feb 6, 2007 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/858
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to cecropin-like polypeptides with a variey of C-terminus modifications. Conversion of the terminal carboxy group to a homoserine extended neutral, negatively charged or positively charged form results in the polypeptides of the invention that have significant bactericidal effects against both Gram-positive and Gram-negative bacteria.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.