Propenone oxime ethers, a method of preparing them, and pharmaceutical compositions containing them
US5166416A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 1, 1989 |
| Grant date | Nov 24, 1992 |
| Priority date | — |
| Expiry date | Dec 1, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2603/24
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to new propenone oxime ethers, a method of preparing them and pharmaceutical compositions containing them. Said new propenone oxime ethers have the formula ##STR1## in which--Ar and Ar' each independentlyl denotes a phenyl group non-substituted, mono or polysubstituted, a 9-anthryl group or a naphthyl group, a pyridyl, thienyl or furyl group; PA0 R.sub.1 R.sub.2 each independently denotes hydrogen, a C.sub.1 -C.sub.4 alkyl group or together with the N-atom to which they are bonded a 1-pyrrolidinyl, piperidino, morpholino or 1-piperazinyl group; PA0 M=H, Cl, Br or a C.sub.1 -C.sub.6 alkyl group PA0 n=2 or 3. The invention also deals with the salts of compounds of formula (I). Said compounds have good activity in the anti platelet-clotting tests and are also antagonists of the 5HT.sub.2 receptors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.