Fermentation and purification process for succinic acid
US5168055A · kind A · utility
Inventors
Key dates
| Filing date | Jun 28, 1989 |
| Grant date | Dec 1, 1992 |
| Priority date | — |
| Expiry date | Jun 28, 2009 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/822
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for economically producing highly purified succinic acid comprises growing a succinate-producing microorganism on a low cost carbohydrate substrate; simultaneously neutralizing the fermentation broth and precipitating the succinate as calcium succinate by adding a calcium ion source to form calcium succinate; isolating the calcium succinate; slurrying the calcium succinate in water and treating it with sulfuric acid to form calcium sulfate and succinic acid; and then treating the succinic acid with first a strongly acidic ion exchanger and then a weakly basic ion exchanger to remove impurities and obtain a highly purified succinic acid product. In a preferred embodiment, the calcium succinate is isolated from the fermentation broth by filtration; the filtrate is heated to precipitate additional calcium succinate; and, the spent filtrate which contains nutrients is recycled to the fermentor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.