Method of detecting the presence of anomalies in exfoliated cells using infrared spectroscopy
US5168162A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Feb 19, 1991 |
| Grant date | Dec 1, 1992 |
| Priority date | — |
| Expiry date | Feb 19, 2011 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N21/35
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The presence of anomalies is detected in exfoliated cells (e.g. in a cervical smear) using infrared spectroscopy. A beam of infrared light is directed at specimens containing cells, which may be secretions, exudates, transudates, scrapings, brushings or otherwise obtained populations of exfoliated cells of various organs or tissues, and the anomaly is detected at at least one range of frequencies by determining whether changes in infrared absorption has occurred which is due to functional group vibration in, for example, phosphodiester groups of nucleic acids, COH groups of tissue proteins, carbohydrates, or due to special arrangements of lipid molecules or abnormal lipid structures, present in the specimen.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.