Monoclonal anti-human breast cancer antibodies
US5169774A · kind A · utility
90Cited by
5References
4Claims
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Key dates
| Filing date | May 6, 1988 |
| Grant date | Dec 8, 1992 |
| Priority date | — |
| Expiry date | May 6, 2008 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/864
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Murine monoclonal antibodies, or fragments thereof, that bind selectively to human breast cancer cells, are IgGs or IgMs, and when conjugated to ricin A chain, exhibit a TCID 50% against at least one of MCF-7, CAMA-1, SKBR-3, or BT-20 cells of less than about 10 nM. Methods for diagnosing, monitoring, and treating human breast cancer with the antibodies or immunotoxins made therefrom are described.
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