Process for the preparation of methyl (-)-(2R,3S)-2,3-epoxy-3-(4-methoxy-phenyl)propionate
US5169779A · kind A · utility
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14Claims
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Key dates
| Filing date | Feb 13, 1991 |
| Grant date | Dec 8, 1992 |
| Priority date | — |
| Expiry date | Feb 13, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P17/02
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A process for the preparation of methyl (-)-(2R,3S)-2,3-epoxy-3-(4-methoxyphenyl)propionate, which comprises subjecting the dextrorotatory (2S,3R) enantiomer, present in a starting mixture containing both the levorotatory (2R,3S and dextrorotatory (2S,3R) enantiomers, to a transesterification reaction, in an anhydrous medium and in the presence of an enzyme which does not affect the levorotatory (2R,3S) enantiomer. The latter is an intermediate for the synthesis of compounds such as Diltiazem.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.