Enantiomeric enrichment and stereoselective synthesis of chiral amines
US5169780A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 9, 1990 |
| Grant date | Dec 8, 1992 |
| Priority date | — |
| Expiry date | Jul 9, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P41/006
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Amines in which the amino group is on a secondary carbon atom which is chirally substituted can be enantiomerically enriched by the action of an omega-amino acid transaminase which has the property of preferentially converting one of the two chiral forms to a ketone. The process can be used to stereoselectively sythesize one chiral form from ketones substantially to the exclusion of the other. An aqueous solution of chiral amines after being brought into contact with an omega-amino acid transaminase and an amino acceptor is treated with a water-immiscible organic solvent, the aqueous and organic phases are separated, and the aqueous phase can be recirculated for further contact with the transaminase.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.