Rapamycin analog as immunosuppressants and antifungals
US5169851A · kind A · utility
105Cited by
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1Claims
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Key dates
| Filing date | Apr 29, 1992 |
| Grant date | Dec 8, 1992 |
| Priority date | — |
| Expiry date | Apr 29, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H19/01
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Reduction of the C-33 ketone of rapamycin gives the C-33 hydroxy analog of Formula I. ##STR1## The reduction product prevents cleavage of the C-31/C-32 bond due to base degradation. The Formula I compounds exhibit immunosupressant, antifungal, and antiinflammatory activities.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.