Anti-tumor compositions containing the reactive product of benzaldehyde or salicylaldehyde with penicillamine and method of use thereof
US5169858A · kind A · utility
Inventor
Key dates
| Filing date | Feb 26, 1986 |
| Grant date | Dec 8, 1992 |
| Priority date | — |
| Expiry date | Feb 26, 2006 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/425
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A composition for therapy of tumors having high tyrosinase activity contains the reaction product of penicillamine with a cytotoxic aldehyde, or pharmaceutically acceptable salts or esters thereof, and a pharmaceutically acceptable vehicle. The preferred compounds are 5,5-dimethyl-2-phenyl-4-thiazolidine carboxylic acid or 5,5-dimethyl-2-(2-hydroxyphenyl)-4-thiazolidine carboxylic acid, or pharmaceutically acceptable salts or esters thereof. Treatment preferably comprises an intra-arterial drip. Diagnosis of tumors suitable for treatment by means of these compositions may be accomplished by administering a radioactive copper salt and scanning for accumulations of radioactivity. This will indicate sites of high tyrosinase activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.