Stereoselective production of hydroxyamide compounds from chiral .alpha.-amino epoxides
US5169952A · kind A · utility
23Cited by
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Key dates
| Filing date | Jul 2, 1991 |
| Grant date | Dec 8, 1992 |
| Priority date | — |
| Expiry date | Jul 2, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K5/0207
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
An efficient process for stereoselective preparation of a medicinally significant hydroxyamide compound of structural formula: ##STR1## comprises the addition of metalated amide enolates to chiral .alpha.-amino metalated epoxides. The hydroxyamide reaction products are useful as inhibitors of the HIV protease or of renin, or as intermediates in the preparation of inhibitors of the HIV protease or renin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.