Cleavable linkers for the reduction of non-target organ retention of immunoconjugates
US5171563A · kind A · utility
29Cited by
19References
34Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 10, 1992 |
| Grant date | Dec 15, 1992 |
| Priority date | — |
| Expiry date | Feb 10, 2012 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/807
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A process for reducing the non-target organ accumulation of immunoconjugates administered in vivo during therapeutic or diagnostic procedures involves the use of immunoconjugates comprising linkers that are cleavable at the non-target organs. The linkers are cleavable under conditions present, or induced, at one or more non-target organs, which include the kidneys or the liver.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.