Bacteriochlorophyll-a derivatives useful in photodynamic therapy
US5171741A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Apr 21, 1989 |
| Grant date | Dec 15, 1992 |
| Priority date | — |
| Expiry date | Apr 21, 2009 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compounds of fomula (1) or formula (2): ##STR1## wherein M is a non-paramagnetic metal selected from Mg.sup.+2, and Zn.sup.+2, or represents 2 H.sup.+ each H.sup.+ bonded to one of the N atoms connected by the solid lines; PA0 R.sup.1 is a saturated or unsaturated hydrocarbyl residue of 8-25C; PA0 each R.sup.2 is independently selected from the group consisting of vinyl, ethyl, acetyl and 1-hydroxyethyl, and PA0 X is COOR.sup.3, wherein R.sup.3 is alkyl (1-4C); are useful in photodynamic therapy and diagnosis. These compounds photosensitize target biological substrates to irradiation, and treating said substrates with these sensitizers followed by irradiation leads to the impairment or destruction of the biological substrate. When administered systemically, these compounds accumulate in the undesired target biological substrate. The compounds can also be utilized in vitro, for example to destroy infectious cells or viruses in blood intended for transfusion.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.