Patent · US Expired

Benzhydryl derivatives having calmodulin inhibitor properties

US5171752A · kind A · utility

5Cited by

1References

6Claims

0Family size

Assignee

Akzo N.V. · NL

Inventors

Patricia Caldirola · Neunburg vorm Wald, DE
Raimund Mannhold · Düsseldorf, DE
Hendrik Timmerman · Voorschoten, NL

Key dates

Filing date	Jul 19, 1991
Grant date	Dec 15, 1992
Priority date	—
Expiry date	Jul 19, 2011

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07C323/25
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The invention relates to a benzhydryl derivative having the formula ##STR1## wherein each of the groups R.sub.1, R.sub.2, and R.sub.3 represents one to four substituents independently selected from the group consisting of hydrogen, lower alkyl, halogen, and CF.sub.3, and at least one of the groups R.sub.1, R.sub.2, and R.sub.3 is halogen or CF.sub.3 ; PA0 R.sub.4 represents hydrogen or methyl; PA0 n is 2, 3, or 4; PA0 m is 1, 2, or 3; and PA0 X represents O or S; PA0 or its pharmaceutically acceptable salts. The benzhydryl derivative of the invention can be used to treat patients who are suffering from diseases which are influenced by calmodulin.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.