Method and apparatus for continuous sample ice matrix production for laser desorption in mass spectrometry
US5171989A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 24, 1992 |
| Grant date | Dec 15, 1992 |
| Priority date | — |
| Expiry date | Jan 24, 2012 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2030/008
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method and apparatus for continuously introducing samples for mass spectrometry analysis which comprises providing sample molecules in an aqueous solution containing one or more organic solvents, preferably ethylene glycol, introducing said aqueous solution into the vacuum chamber of an ion source to enable said solution to solidify into a thread of solid matrix, and exposing the solid matrix to a source of energy to desorb sample molecules to be analyzed. The desorbed molecules are then photoionized and focused into a mass spectral analysis zone. The technique is suitable for interfacing liquid chromatographic separation techniques.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.