Microorganisms suitable for producing compounds containing a terminal hydroxyl or epoxy group
US5173428A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 1, 1991 |
| Grant date | Dec 22, 1992 |
| Priority date | — |
| Expiry date | Apr 1, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P17/02
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
This invention relates to a process for the microbiological production of compounds containing a terminal hydroxyl or epoxy group from an aliphatic substrate or a substrate with an aliphatic side chain, using microorganisms genetically engineered so that they have retained their capacity to perform the terminal oxidation of the substrate, but are no longer able to convert the resulting oxidation product further to any significant extent. Preferred substrates are n-alkanes, n-alkenes, and n-alkadienes containing 6-12 carbon atoms. Preferred micro-organisms are genetically engineered Pseudomonas oleovorans and Pseudomonas putida strains lacking an active plasmidic alkanol-dehydrogenase gene. The invention also relates to micro-organisms thus genetically engineered.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.