Compounds which inhibit complement and/or suppress immune activity
US5173499A · kind A · utility
8Cited by
14References
13Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Apr 15, 1988 |
| Grant date | Dec 22, 1992 |
| Priority date | — |
| Expiry date | Apr 15, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D307/94
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention is directed to compounds which suppress immune responses and/or selectively inhibit complement. These compounds contain an aromatic ring and are substituted dihydrobenzofurans, spirobenzofuran-2(3H)-cycloalkanes, and their open chain intermediates. The compounds of the present invention, and the pharmaceutically acceptable salts thereof, interrupt the proteolytic processing of C5 to bioactive components, exhibit immunosuppressive activities, and have therapeutic utility in the amelioration of disease and disorders mediated by complement and/or immune activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.