Bacteriochlorophyll-a derivatives useful in photodynamic therapy
US5173504A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jan 3, 1991 |
| Grant date | Dec 22, 1992 |
| Priority date | — |
| Expiry date | Jan 3, 2011 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K41/0071
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compounds of formula (1) or formula (2): ##STR1## wherein M is a non-paramagnetic metal selected from Mg.sup.+2, Sn.sup.+2, and Zn.sup.+2, or represents 2 H.sup.30 each H.sup.+ bonded to one of the N atoms connected by the solid lines; PA1 R.sup.1 is a saturated of unsaturated hydrocarbyl residue of 8-25 C.; PA1 each R.sup.2 is independently selected from the group consisting of vinyl, ethyl, acetyl and 1-hydroxyethyl, and PA1 X is COOR.sup.3, wherein R.sup.3 is alkyl (1-C); are useful in photodynamic therapy and diagnosis. These compounds photosensitize target biological substrates to irradiation, and treating said substrates with these sensitizers followed by irradiation leads to the impairment or destruction of the biological substrate. When administered systemically, these compounds accumulate in the undesired target biological substrate. The compounds can also be utilized in vitro, for example to destroy infectious cells or viruses in blood intended for transfusion.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.