Pharmaceutically active pyrimidinylpiperazinylsterioids

US5175281A · kind A · utility

Assignee

• The Upjohn Co. · US

Inventors

• John M. McCall · Kalamazoo, US
• Donald E. Ayer · Kalamazoo, US
• E. Jonathan Jacobsen · Plainwell, US
• Frederick J. VanDoornik · Hamilton, US
• John R. Palmer · Fishers, US
• Harold A. Karnes · Kalamazoo, US

Key dates

• Filing date: Aug 26, 1991
• Grant date: Dec 29, 1992
• Expiry date: Aug 26, 2011

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J43/003
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed are .DELTA..sup.9(11) -steroids (VI) and amino substituted steroids (XI) which contain an amino group attached to the terminal carbon atom of the C.sub.17 -side chain, more particularly amino steroids (Ia and Ib), aromatic steroids (II), .DELTA..sup.16 -steroids (IIIa and IIIb), reduced A-ring steroids (IV), .DELTA..sup.17(20) -steroids (Va and Vb) and .DELTA..sup.9(11) -steroids (VI) which are useful as pharmaceutical agents for treating a number of conditions.