Process for preparing purine derivatives and intermediates thereof
US5175288A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 9, 1990 |
| Grant date | Dec 29, 1992 |
| Priority date | — |
| Expiry date | Apr 9, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D473/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for preparing pharmaceutically active compounds of formula (A): ##STR1## wherein X is hydrogen, hydroxy, chloro, C.sub.1-6 alkoxy or phenyl C.sub.1-6 alkoxy; and R.sub.a and R.sub.b are hydrogen, or acyl or phosphate derivatives thereof, which process comprises the preparation of an intermediate of formula (I): ##STR2## wherein R.sub.1 is C.sub.1-6 alkyl, or phenyl C.sub.1-6 alkyl in which the phenyl group is optionally substituted; R.sub.2 is hydrogen, hydroxy, chlorine, C.sub.1-6 alkoxy, phenyl C.sub.1-6 alkoxy or amino; and R.sub.3 is halogen, C.sub.1-6 alkylthio, C.sub.1-6 alkylsulphonyl, azido, an amino group or a protected amino group, via the reaction of a compound of formula (II): ##STR3## wherein R.sub.2 and R.sub.3 are as defined for formula (I) with: (a) a compound of formula (III): ##STR4## wherein R.sub.4 and R.sub.5 are independently hydrogen, C.sub.1-6 alkyl, or phenyl, or R.sub.4 and R.sub.5 together are C.sub.5-7 cycloalkyl; or PA0 (b), a compound of formula (V): ##STR5## wherein L is a leaving group and R.sub.1 is as defined for formula (I), and thereafter converting the resulting intermediates to a compound of formula (I) and converting a compound of fo…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.