Virus-resistant transgenic mice
US5175385A · kind A · utility
77Cited by
3References
8Claims
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Key dates
| Filing date | Sep 3, 1987 |
| Grant date | Dec 29, 1992 |
| Priority date | — |
| Expiry date | Sep 3, 2007 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA01K2267/02
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A transgenic mouse with enhanced viral resistance transmissible to its offspring is prepared by introduction of a gene encoding a human interferon having antiviral activity into a host mouse. The gene encodes the interferon of a different animal species and therefore its expression product is less toxic to the host at an embryonic, fetal, neonatal or junvenile stage of development. Preferably, the human beta interferon gene is introduced into the cells of a mouse.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.