Antimicrobial dentifrice
US5176899A · kind A · utility
Inventor
Key dates
| Filing date | Nov 25, 1991 |
| Grant date | Jan 5, 1993 |
| Priority date | — |
| Expiry date | Nov 25, 2011 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61Q11/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A stabilized aqueous dentifrice composition capable of producing or, in the presence of saliva, leading to the production of antimicrobially effective concentrations of hypothiocyanite ions (OSCN--) are herein described. The composition contains both an oxidoreductase enzyme and its specific substrate, for the purpose of producing hydrogen peroxide of at least the minimum effective concentration. The aqueous dentifrice compositions of the present invention can be stabilized against premature enzyme/substrate interaction by controlling the level of dissolved oxygen in the aqueous dentifrice carrier. Optionally, a peroxidase enzyme may be included to act upon the aforementioned hydrogen peroxide, thereby oxidizing salivary thiocyanate ions to produce the antimicrobial concentrations of hypothiocyanite ions (OSCN--). Optionally, thiocyanate ions may also be included in the compositions of this invention in an amount sufficient, together with the other inventive ingredients, to produce in excess of about 100 micromoles/liter/minute of hypothiocyanite ions during use. The amount of water contained in dentifrice compositions is not important to the stability of the composition, provided …
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.