1,4-disubstituted piperazines
US5177077A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 11, 1991 |
| Grant date | Jan 5, 1993 |
| Priority date | — |
| Expiry date | Jul 11, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D333/16
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A disubstituted piperazine compound having the formula I ##STR1## wherein R.sup.1 is thienyl or phenyl, which may be substituted with C.sub.1-6 -alkyl or halogen, and R.sup.2 is thienyl, which may be substituted with C.sub.1-6 -alkyl or halogen, and R.sup.3 is C.sub.1-8 -alkyl, C.sub.3-8 -alkenyl or C.sub.3-8 -cycloalkyl which all may be substituted with hydroxy, oximino or keto in any position giving a stable tertiary amine or R.sup.3 is C.sub.1-8 -alkyl or C.sub.3-8 -alkenyl which in any position may be substituted as above, but is terminally substituted with phenoxy, phenyl, thienyl, furyl, methoxy or --CN and pharmaceutically acceptable acid addition salts thereof. The compounds are useful in the treatment of mental disorders in which a dopaminergic deficit is implicated.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.