Isolated nucleotide sequence expressing human transforming growth factor-.beta.1-binding protein
US5177197A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 27, 1990 |
| Grant date | Jan 5, 1993 |
| Priority date | — |
| Expiry date | Feb 27, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/47
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Purified protein known as platelet TGF-.beta.1-BP (transforming growth factor-.beta.1-binding protein) is described. The protein is useful for purposes such as the production of antisera which are useful in identifying complexes containing the binding protein, as well as in formation of labeled probes. Also described are purified DNA which expresses the protein, as well as messenger RNA translated into the protein. The protein contains 16 epidermal growth factors (EGF) like repeats, and 3 repeats not found in other proteins. The DNA for the protein is found to contain consensus sequences for hydroxylation of asparagine/aspartic acid residues, and, in the purified protein beta hydroxylated asparagine residues were found.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.