Method for preparing a phosphonic acid ester
US5177239A · kind A · utility
5Cited by
2References
10Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 17, 1989 |
| Grant date | Jan 5, 1993 |
| Priority date | — |
| Expiry date | Jul 17, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/4006
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method is provided for preparing a phosphonic acid ester having the structure ##STR1## wherein R.sup.1 is farnesyl or a derivative or analog thereof, and R.sup.2 is lower alkyl, by treating a farnesyl halide R.sup.1 Hal(Hal.dbd.Cl,Br,I) with an alkoxide of the structure ##STR2## wherein M is an alkali metal and R.sup.2c is lower alkyl. The resulting phosphonic acid ester is an intermediate in preparing a squalene synthetase inhibitor which is used for inhibiting cholesterol biosynthesis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.