Synthesis of ioversol using chloroacetyl chloride

US5177261A · kind A · utility

Assignee

• MallincKrodt Medical, Inc. · US

Inventors

• William Z. McCarthy · Chesterfield, US
• Mills T. Kneller · University City, US
• Youlin Lin · Chesterfield, US
• David H. White · Ballwin, US

Key dates

• Filing date: Jul 22, 1991
• Grant date: Jan 5, 1993
• Expiry date: Jul 22, 2011

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C237/46
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The use of chloroacetylchloride as an alternative or substitute reagent for acetoxychloride in the synthesis of N,N'- bis (2,3-dihydroxypropyl)-5-N-(2-hydroxyethyl)glycolamido-2,4,6-triiodoisophth alamide.