Liposomal-polyene preliposomal powder and method for its preparation
US5178875A · kind A · utility
23Cited by
19References
68Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 14, 1991 |
| Grant date | Jan 12, 1993 |
| Priority date | — |
| Expiry date | Jan 14, 2011 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T428/2985
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method is disclosed for preparing a stable preliposomal powder which, when reconstituted with water or saline solution, forms a suspension of liposomes containing a polyene drug, such as nystatin. The method involves the steps of combining at least one phospholipid with a first organic solvent to form a first solution, adding a clarifying amount of water to the first solution, combining a polyene with a second organic solvent to form a second solution, combining the first and second solutions to produce a substantially clear combined solution, and then removing the organic solvents, leaving a powder.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.